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The release of a platelet-activating factor by stimulated rabbit neutrophils.

Authors
Type
Published Article
Journal
Journal of immunology (Baltimore, Md. : 1950)
Publication Date
Volume
123
Issue
3
Pages
1219–1226
Identifiers
PMID: 469247
Source
Medline

Abstract

Normal rabbit peripheral blood neutrophils released a platelet-activating factor upon stimulation by opsonized zymosan. The liberation was Ca++ dependent and the time course of release was closely associated with phagocytosis. The material extracted into chloroform and exhibited an identical mobility by thin layer chromatography to basophil-derived, IgE-stimulated, platelet-activating factor (PAFb). It was similar to PAFb in its effect on platelets in both aggregation and release but was distinguished from ADP, thrombin, arachidonic acid, and thromboxanes. This factor appears to be responsible for some previously reported neutrophil-platelet interactions.

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