Affordable Access

deepdyve-link
Publisher Website

Release mechanisms of major DAMPs

Authors
  • Murao, Atsushi1
  • Aziz, Monowar1
  • Wang, Haichao2, 3
  • Brenner, Max1, 3
  • Wang, Ping1, 3, 3
  • 1 Center for Immunology and Inflammation, The Feinstein Institutes for Medical Research, 350 Community Dr., Manhasset, NY 11030 USA
  • 2 Center for Biomedical Science, The Feinstein Institutes for Medical Research, Manhasset, NY USA
  • 3 Zucker School of Medicine at Hofstra/Northwell,
Type
Published Article
Journal
APOPTOSIS
Publisher
Springer-Verlag
Publication Date
Mar 13, 2021
Volume
26
Issue
3
Pages
152–162
Identifiers
DOI: 10.1007/s10495-021-01663-3
PMID: 33713214
PMCID: PMC8016797
Source
PubMed Central
Keywords
Disciplines
  • Review
License
Unknown

Abstract

Damage-associated molecular patterns (DAMPs) are endogenous molecules which foment inflammation and are associated with disorders in sepsis and cancer. Thus, therapeutically targeting DAMPs has potential to provide novel and effective treatments. When establishing anti-DAMP strategies, it is important not only to focus on the DAMPs as inflammatory mediators but also to take into account the underlying mechanisms of their release from cells and tissues. DAMPs can be released passively by membrane rupture due to necrosis/necroptosis, although the mechanisms of release appear to differ between the DAMPs. Other types of cell death, such as apoptosis, pyroptosis, ferroptosis and NETosis, can also contribute to DAMP release. In addition, some DAMPs can be exported actively from live cells by exocytosis of secretory lysosomes or exosomes, ectosomes, and activation of cell membrane channel pores. Here we review the shared and DAMP-specific mechanisms reported in the literature for high mobility group box 1, ATP, extracellular cold-inducible RNA-binding protein, histones, heat shock proteins, extracellular RNAs and cell-free DNA.

Report this publication

Statistics

Seen <100 times