Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Relaxivities of paramagnetic liposomes: on the importance of the chain type and the length of the amphiphilic complex.

Authors
  • Laurent, Sophie
  • Vander Elst, Luce
  • Thirifays, Coralie
  • Muller, Robert N
Type
Published Article
Journal
European biophysics journal : EBJ
Publication Date
Jul 01, 2008
Volume
37
Issue
6
Pages
1007–1014
Identifiers
DOI: 10.1007/s00249-008-0331-y
PMID: 18427798
Source
Medline
License
Unknown

Abstract

Nuclear magnetic relaxation dispersion (NMRD) profiles of unilamellar DPPC liposomes incorporating Gd-DTPA-bisamides with alkyl chains of 12 to 18 C atoms in their external and internal layers were recorded in order to study the influence that the chain length and structure of Gd-bisamides incorporated in the liposomal membrane have on their proton relaxivity. The NMRD profiles recorded at 310 K show that the relaxivity reaches a minimum value when the carbon chain lengths of the phospholipid and of the Gd complex match and is at a maximum in the presence of a carbon-carbon double bond. For these DPPC paramagnetic liposomes, the longer the aliphatic chains of the complex, the larger will be its immobilization in the membrane. In addition, the presence of an unsaturated carbon-carbon bond in the alkyl chain of the Gd complex induces an increase of its mobility and of its water exchange rate with, as a result, a much greater efficiency as an MRI contrast agent.

Report this publication

Statistics

Seen <100 times