Affordable Access

RELATIVE STABILITY OF PERTUSSIS VACCINE PRESERVED WITH MERTHIOLATE, BENZETHONIUM CHLORIDE, OR THE PARABENS.

Authors
  • GARDNER, R A
  • PITTMAN, M
Type
Published Article
Journal
Applied microbiology
Publication Date
Jul 01, 1965
Volume
13
Pages
564–569
Identifiers
PMID: 14339263
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

When stored at 4 C, or heated at 22 or 35 C followed by storage at 4 C, the potency of pertussis vaccines preserved with Merthiolate was more stable than the potency of vaccines preserved with benzethonium chloride or the parabens (methyl- and propyl-p-hydroxybenzoate). Without preservative, potency was more stable than in the presence of benzethonium chloride or the parabens, but less stable than when Merthiolate was present. The histamine-sensitizing factor of the vaccines likewise decreased with the loss of potency. The deleterious effect of benzethonium chloride and the absence of the stabilizing effect of Merthiolate were contributing factors, if not the sole cause, for the instability of pertussis vaccine in quadruple antigen vaccine (diphtheria and tetanus toxoids and pertussis and poliomyelitis vaccines).

Report this publication

Statistics

Seen <100 times