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Relative resistance to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposure.

Authors
  • Paxton, W A
  • Martin, S R
  • Tse, D
  • O'Brien, T R
  • Skurnick, J
  • VanDevanter, N L
  • Padian, N
  • Braun, J F
  • Kotler, D P
  • Wolinsky, S M
  • Koup, R A
Type
Published Article
Journal
Nature medicine
Publication Date
Apr 01, 1996
Volume
2
Issue
4
Pages
412–417
Identifiers
PMID: 8597950
Source
Medline
License
Unknown

Abstract

Some individuals remain uninfected with human immunodeficiency virus type-1 (HIV-1) despite multiple high-risk sexual exposures. We studied a cohort of 25 subjects with histories of multiple high-risk sexual exposures to HIV-1 and found that their CD8+ lymphocytes had greater anti-HIV-1 activity than did CD8+ lymphocytes from nonexposed controls. Further studies indicated that their purified CD4+ lymphocytes were less susceptible to infection with multiple primary isolates of HIV-1 than were CD4+ lymphocytes from the nonexposed controls. This relative resistance to HIV-1 infection did not extend to T-cell line-adapted strains, was restricted by the envelope glycoprotein, was not explained by the cell surface density of CD4 molecules, but was associated with the activity of the C-C chemokines RANTES, MIP-1alpha, and MIP-1beta. This relative resistance of CD4+ lymphocytes may contribute to protection from HIV-1 in multiply exposed persons.

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