Relative configuration of JBIR-129, a cytotoxic 34-membered glycosidic polyol macrolide from Streptomyces sp. RK74.
- Authors
- Type
- Published Article
- Journal
- Organic Letters
- Publisher
- American Chemical Society
- Publication Date
- Sep 07, 2012
- Volume
- 14
- Issue
- 17
- Pages
- 4434–4437
- Identifiers
- DOI: 10.1021/ol301940q
- PMID: 22908979
- Source
- Medline
- License
- Unknown
Abstract
JBIR-129 was isolated as the potent cytotoxic compound, which consists of the 34-membered polyol macrolide skeleton with five sugar moieties. The relative configuration of the aglycone moiety (C7-C27 and C33-C39) was established by the J-based configuration analysis using vicinal (1)H-(1)H (from (1)H NMR and PS-DQF-COSY spectra) and long-range (1)H-(13)C coupling constants (from sge-HETLOC and several J-resolved HMBC spectra) with steric information obtained from ROESY.
