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Relative binding constants of arsenical-antidote adducts determined by NMR spectroscopy.

Authors
  • O'Connor, R J
  • McGown, E L
  • Dill, K
  • Hallowell, S F
Type
Published Article
Journal
Research communications in chemical pathology and pharmacology
Publication Date
Sep 01, 1990
Volume
69
Issue
3
Pages
365–368
Identifiers
PMID: 2173085
Source
Medline
License
Unknown

Abstract

Proton nuclear magnetic resonance spectroscopy was used to determine relative binding constants for several arsenical-antidote adducts. It was found that BAL (2,3-dimercaptopropanol) and DMPS (2,3-dimercaptopropanesulfonic acid) had a higher affinity than DMSA (2,3-dimercaptosuccinic acid) for the two organic arsenicals studied.

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