Affordable Access

deepdyve-link
Publisher Website

Relationships between regional cerebellar volume and sensorimotor and cognitive function in young and older adults.

Authors
  • Bernard, Jessica A1
  • Seidler, Rachael D
  • 1 Department of Neurology, University of Colorado Denver, School of Medicine, 13001 E. 17th Place, Building 500, N3200, Aurora, CO, 80045, USA. [email protected]
Type
Published Article
Journal
Cerebellum (London, England)
Publication Date
Oct 01, 2013
Volume
12
Issue
5
Pages
721–737
Identifiers
DOI: 10.1007/s12311-013-0481-z
PMID: 23625382
Source
Medline
License
Unknown

Abstract

The cerebellum has been implicated in both sensorimotor and cognitive function, but is known to undergo volumetric declines with advanced age. Individual differences in regional cerebellar volume may therefore provide insight into performance variability across the lifespan, as has been shown with other brain structures and behaviors. Here, we investigated whether there are regional age differences in cerebellar volume in young and older adults, and whether these volumes explain, in part, individual differences in sensorimotor and cognitive task performance. We found that older adults had smaller cerebellar volume than young adults; specifically, lobules in the anterior cerebellum were more impacted by age. Multiple regression analyses for both age groups revealed associations between sensorimotor task performance in several domains (balance, choice reaction time, and timing) and regional cerebellar volume. There were also relationships with working memory, but none with measures of general cognitive or executive function. Follow-up analyses revealed several differential relationships with age between regional volume and sensorimotor performance. These relationships were predominantly selective to cerebellar regions that have been implicated in cognitive functions. Therefore, it may be the cognitive aspects of sensorimotor task performance that are best explained by individual differences in regional cerebellar volumes. In sum, our results demonstrate the importance of regional cerebellar volume with respect to both sensorimotor and cognitive performance, and we provide additional insight into the role of the cerebellum in age-related performance declines.

Report this publication

Statistics

Seen <100 times