Affordable Access

Relationship of traditional and nontraditional cardiovascular risk factors to coronary artery calcium in type 2 diabetes.

Authors
  • Mazzone, Theodore
  • Meyer, Peter M
  • Kondos, George T
  • Davidson, Michael H
  • Feinstein, Steven B
  • D'Agostino, Ralph B Sr
  • Perez, Alfonso
  • Haffner, Steven M
Type
Published Article
Journal
Diabetes
Publisher
American Diabetes Association
Publication Date
Mar 01, 2007
Volume
56
Issue
3
Pages
849–855
Identifiers
PMID: 17327456
Source
Medline
License
Unknown

Abstract

We evaluated correlates of coronary atherosclerosis, measured by coronary artery calcium, in a racially diverse group of male and female subjects with type 2 diabetes. Age, systolic blood pressure, sex, and race/ethnicity were significant determinants of coronary artery calcium. Among lipoproteins, cholesterol level contained in a particle excluded from direct measures of LDL and HDL cholesterol (designated triglyceride-rich lipoprotein cholesterol) was most strongly linked to coronary artery calcium. Neither inflammatory markers nor metabolic factors correlated with coronary artery calcium in models adjusted for age and sex, but measures of adipose distribution did. Waist-to-hip ratio and the ratio of visceral to total abdominal tissue were positively associated with coronary artery calcium. In fully adjusted multivariate models, the relationship of adiposity measures to coronary artery calcium was no longer significant after inclusion of apolipoprotein B or triglyceride-rich lipoprotein cholesterol. Traditional risk factors and race/ethnicity remain important correlates of coronary artery calcium in a cohort at elevated risk of cardiovascular disease because of type 2 diabetes. Adiposity measures are significantly associated with coronary artery calcium score, but their importance may be largely explained by apolipoprotein B or triglyceride-rich lipoprotein cholesterol.

Report this publication

Statistics

Seen <100 times