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The Relationship of Helicobacter pylori Colonization, the Serum Pepsinogen A Level, and Gastric Resection

Authors
  • Chang, Full-Young1
  • Lu, Ching-Liang1
  • Chen, Tseng-Shing1
  • Hou, Ming-Chih1
  • Lee, Shou-Dong1
  • 1 Division of Gastroenterology, Veterans General Hospital-Taipei and National Yang Ming University, 201 Shih-Pai Road, Section 2, Taipei, Taiwan 11217, Republic of China, TW
Type
Published Article
Journal
Surgery Today
Publisher
Springer-Verlag
Publication Date
Jan 01, 1998
Volume
28
Issue
2
Pages
139–144
Identifiers
DOI: 10.1007/s005950050095
Source
Springer Nature
Keywords
License
Yellow

Abstract

(HP) colonization has any influence. Included in this study were 48 patients who underwent subtotal gastrectomy for a peptic ulcer (SGPU), 36 who underwent radical subtotal gastrectomy for gastric carcinoma (SGGC), 16 who underwent truncal vagotomy plus antrectomy (TV + AE), 24 with recurrent ulcer (RU) and 27 who underwent total gastrectomy (TG). The mean serum PGA levels in these five groups and in 40 healthy controls were 49.1 ± 30.4 ng/ml, 30.0 ± 14.8 ng/ml, 44.8 ± 21.7 ng/ml, 66.4 ± 42.8 ng/ml, 8.7 ± 3.0 ng/ml, and 94.7 ± 27.9 ng/ml, respectively. All patients except those with RU showed a diminished PGA level. The HP colonization rates of the patients who underwent partial resection were 45.8%, 22.2%, 50%, and 54.2%, respectively (P < 0.05). Age, gender, smoking, the type of gastroenterostomy, and underlying disease did not exert any influence on the measured PGA levels. However, higher PGA levels were observed in HP-colonized patients who either underwent SGPU or had RU. We conclude that various forms of distal gastrectomy, but not RU, elicit an indistinguishable acid secretory ability while HP colonization is responsible for the higher serum PGA levels in some patients following peptic ulcer surgery.

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