Affordable Access

deepdyve-link
Publisher Website

The relationship of cardiorespiratory function, fatigue and depressive symptoms in PLHIV.

Authors
  • Horvat Davey, Christine1
  • Perazzo, Joseph D2
  • Vest, Marianne3
  • Josephson, Richard A4, 5
  • Oliveira, Vitor H F6
  • Sattar, Abdus4
  • Webel, Allison R1
  • 1 Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA. , (France)
  • 2 College of Nursing, University of Cincinnati, Cincinnati, OH, USA.
  • 3 Center for Clinical Investigation, Case Western Reserve University, Cleveland, OH, USA.
  • 4 School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
  • 5 Division of Cardiovascular Medicine, Harrington Heart & Vascular Institute, University Hospitals Health System, Cleveland, OH, USA.
  • 6 Department of Physical Education, State University of Londrina, Londrina, Brazil. , (Brazil)
Type
Published Article
Journal
AIDS care
Publication Date
Jul 01, 2020
Volume
32
Issue
7
Pages
877–881
Identifiers
DOI: 10.1080/09540121.2019.1659920
PMID: 31470737
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Fatigue and depressive symptoms are prevalent and associated with poor clinical outcomes, though the underlying physiological mechanisms of fatigue and depression are poorly understood. We examined the impact of cardiorespiratory fitness (CRF) on fatigue and depressive symptoms in one-hundred and nine PLHIV. CRF was examined by maximal cardiorespiratory stress test and determined by peak oxygen uptake. Patient-reported fatigue was examined utilizing the HIV-Related Fatigue Scale. Depressive symptoms were examined with the Beck Depression Inventory and PROMISE 29. Data was collected at baseline and six months. Generalized estimating equations were used to determine the effect of CRF on fatigue and depressive symptoms over time. Participants were approximately 53 years old, 86% African American (n = 93), and 65% male (n = 70). After controlling for age and sex, fatigue was inversely associated with CRF (β = -0.163; p = .005). Depressive symptoms were not associated with CRF as measured by the Beck Depression Inventory (p = .587) nor PROMIS 29 (p = .290), but over time, depressive symptoms decreased (p = .051). Increased CRF was associated with decreased fatigue levels, but was not associated with depressive symptoms. These results should guide future research aimed at how CRF might inform interventions to improve fatigue in PLHIV.

Report this publication

Statistics

Seen <100 times