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Relationship Between Serum Levels of Arsenic, Cadmium, and Mercury and Body Mass Index and Fasting Plasma Glucose in a Mexican Adult Population.

Authors
  • Hernández-Mendoza, Héctor1, 2
  • Álvarez-Loredo, Héctor Edmundo3
  • Romero-Guzmán, Elizabeth Teresita4
  • Gaytán-Hernández, Darío5
  • Chang-Rueda, Consuelo6
  • Martínez-Navarro, Israel3
  • Juárez-Flores, Bertha Irene7
  • Rios-Lugo, María Judith8, 9
  • 1 Instituto de Investigación de Zonas Desérticas, Universidad Autónoma de San Luis Potosí, Altair 200, C.P: 78377, San Luis Potosí, S.L.P., México. [email protected]
  • 2 Universidad del Centro de México, Capitán Caldera 75, C.P: 78250, San Luis Potosí, S.L.P., México. [email protected]
  • 3 Centro de Investigación en Ciencias de Salud y Biomedicina, Sección de Medicina Molecular y Traslacional, Universidad Autónoma de San Luis Potosí, Avda Sierra Leona 550, C.P: 78210, San Luis Potosí, S.L.P., México.
  • 4 Departamento de Química, Gerencia de Ciencias Básicas, Dirección de Investigación Científica, Carretera México-Toluca S/N, C.P: 52750, La Marquesa Ocoyoacác, México.
  • 5 Facultad de Enfermería Y Nutrición, Unidad de Posgrado, Universidad Autónoma de San Luis Potosí, Avda. Niño Artillero 130, C.P: 78210, San Luis Potosí, S.L.P., México.
  • 6 Facultad de Ciencias Químicas, Universidad Autónoma de Chiapas, Campus IV Carretera a Puerto Madero Km 1.5, C.P: 30580, Tapachula, Chiapas, México.
  • 7 Instituto de Investigación de Zonas Desérticas, Universidad Autónoma de San Luis Potosí, Altair 200, C.P: 78377, San Luis Potosí, S.L.P., México.
  • 8 Centro de Investigación en Ciencias de Salud y Biomedicina, Sección de Medicina Molecular y Traslacional, Universidad Autónoma de San Luis Potosí, Avda Sierra Leona 550, C.P: 78210, San Luis Potosí, S.L.P., México. [email protected]
  • 9 Facultad de Enfermería Y Nutrición, Unidad de Posgrado, Universidad Autónoma de San Luis Potosí, Avda. Niño Artillero 130, C.P: 78210, San Luis Potosí, S.L.P., México. [email protected]
Type
Published Article
Journal
Biological Trace Element Research
Publisher
Springer-Verlag
Publication Date
Dec 01, 2022
Volume
200
Issue
12
Pages
4916–4923
Identifiers
DOI: 10.1007/s12011-021-03081-7
PMID: 35098445
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

In Mexico, few studies have analyzed the associations between toxic elements and metabolic diseases. In the present study, we analyzed the associations between serum arsenic (As), cadmium (Cd), and mercury (Hg) levels and body mass index (BMI) and fasting plasma glucose (FPG) in a Mexican adult population. Anthropometric data corresponding to 86 Mexican healthy adults (59 females and 27 men) were analyzed. FPG was analyzed by an enzymatic colorimetric method, and serum As, Cd, and Hg levels were analyzed by inductively coupled plasma-mass spectrometry (ICP-MS). The data show that the median serum As, Cd, and Hg levels were relatively higher in females (As = 1.78 ng mL-1, Cd = 1.00 ng mL-1, Hg = 0.96 ng mL-1) than those in males (As = 1.22 ng mL-1, Cd = 0.91 ng mL-1, Hg = 0.95 ng mL-1). However, these differences were not statistically significant (p ≥ 0.097). We also found that the median level of As significantly increased with an increase in the body weight categories (normal weight = 1.08; overweight = 1.50; obesity = 2.75; p < 0.001). In addition, a positive association between serum As levels and FPG before and after adjustment for BMI was demonstrated (RhoUnadjusted = 0.012; (RhoAdjusted = 0.243, p = 0.032). Serum As levels are positively associated with BMI and FPG in the adult population of Mexico. Nevertheless, these results need to be replicated and confirmed with a larger sample size. © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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