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The relationship between rat intestinal permeability and hydrophilic probe size.

Authors
Type
Published Article
Journal
Pharmaceutical research
Publication Date
Volume
13
Issue
10
Pages
1554–1558
Identifiers
PMID: 8899850
Source
Medline
License
Unknown

Abstract

For large hydrophilic probes and possibly protein drugs, cross sectional diameter is a more important size parameter than volume based values for evaluating size-related retarded absorption. The relationship established may be used as a tool to assess absorption enhancement potential of excipients.

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