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[Relationship between the quality of the inoculum material and carminomycin biosynthesis by a culture of Actinomadura carminata].

Authors
Type
Published Article
Journal
Antibiotiki
Publication Date
Volume
22
Issue
4
Pages
312–316
Identifiers
PMID: 18979
Source
Medline
License
Unknown

Abstract

The effect of the inoculum mycelium quality on carminomycin biosynthesis by Actinomadura carminata was studied. The time of the organism growth on the culture medium containing cornsteep liquor continued for 6 hours without losing by the inoculum of its seeding qualities during that period. The mycelium growth in the inoculum was more intensive under conditions of moderate aeration, i.e. 0.98-2.64 mg O2H1-min. Anincrease in the aeration rate up to 18.56 mg O2/1-min resulted in the growth suppression up to 40 per cent. No correlation between the aeration rate during the inoculum growth and the culture capacity for carminomycin biosynthesis and of the content of the complex in active components the fermentation medium were observed, when a 5-10 per cent of inoculum was used.

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