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The relationship between the metabolic syndrome and arterial wall thickness: A mosaic still to be interpreted.

  • Scuteri, Angelo1
  • Franco, Oscar H2
  • Majiid, AlGhatrif3
  • Jolita, Badariene4
  • Sergey, Boytsov5
  • Cheng, Hao-Min6
  • Chen, Chen-Huan6
  • Choi, Seong-Woo7
  • Francesco, Cucca8
  • De Buyzere, Marc L9
  • Alessandro, Delitala8
  • Marcus, Dörr10
  • Gunnar, Engstrom11
  • Albert, Hofman2
  • Seul-Ki, Jeong12
  • Kweon, Sun-Seog13
  • Michel, Langlois14
  • Lee, Young-Hoon15
  • Mattace Raso, Francesco2
  • Olle, Melander11
  • And 14 more
  • 1 Department of Medicine, UOC Hypertension and Nephrology, Policlinico Tor Vergata, Rome, Italy. Electronic address: [email protected] , (Italy)
  • 2 Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands. , (Netherlands)
  • 3 Laboratory Cardiovascular Sciences, National Institute on Aging (NIA), NIH, Baltimore, USA.
  • 4 Centre of Cardiology and Angiology, Vilnius University Hospital Santariškių Klinikos, Vilnius, Lithuania. , (Lithuania)
  • 5 Department of Aging and Age-associated Diseases Prevention, National Research Center for Preventive Medicine, Moscow, Russian Federation. , (Russia)
  • 6 Department of Public Health - and Cardiovascular Research Center, National Yang-Ming University, Taipei, Taiwan. , (Taiwan)
  • 7 Department of Preventive Medicine, Chosun University Medical School, Gwangju, Republic of Korea. , (North Korea)
  • 8 Institute of Genetics and Biomedic Research (IRGB), Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy. , (Italy)
  • 9 Bimetra, Clinical Research Center Ghent, Ghent University Hospital, Ghent, Belgium. , (Belgium)
  • 10 DZHK (German Center for Cardiovascular Research), partner site Greifswald, Germany; Department of Internal Medicine B, University Medicine Greifswald, Germany. , (Germany)
  • 11 Department of Clinical Sciences, Lund University, University Hospital, Malmö, Sweden. , (Sweden)
  • 12 Department of Neurology & Research Institute of Clinical Medicine, Chobuk National University-Biomedical Institute of Chonbuk National University Hospital, Jeonju, Republic of Korea. , (North Korea)
  • 13 Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea. , (North Korea)
  • 14 Clinical Chemistry, AZ Saint-Jan Bruges Hospital, Asklepios Core Lab, And Department of Cardiovascular Diseases, Ghent University, Ghent, Belgium. , (Belgium)
  • 15 Department of Preventive Medicine & Institute of Wonkwang Medical Science, Wonkwang University College of Medicine, Iksan, Republic of Korea. , (North Korea)
  • 16 Laboratory Cardiovascular Sciences, National Institute on Aging (NIA), NIH, Baltimore, USA; Loyola College, Baltimore, USA.
  • 17 Department of Preventive Medicine, Seonam University College of Medicine, Namwon, Republic of Korea. , (North Korea)
  • 18 Laboratory of Genetics, National Institute on Aging (NIA), NIH, Baltimore, USA.
Published Article
Publication Date
Dec 01, 2016
DOI: 10.1016/j.atherosclerosis.2016.10.032
PMID: 27794213


We aimed to identify clusters of metabolic syndrome (MetS) components, risky for extremely high intima-media thickness. We studied 41,513 volunteers (men and women) from eleven cohorts worldwide, participating in the MARE (Metabolic syndrome and Artery REsearch) Consortium. Specific clusters of MetS components - high triglycerides-high blood pressure-abdominal obesity (TBW), low HDL cholesterol-high blood pressure-abdominal obesity (HBW), high glucose-high blood pressure-abdominal obesity (GBW) - were accompanied by a 50-90% significantly greater likelihood of presenting extremely high intima-media thickness (via ultrasound of carotid artery, CCA IMT), after controlling for age, sex, smoking, non-HDL cholesterol, and presence of diabetes mellitus. This likelihood is comparable to the effect of being 7-8 years older or of being a cigarette smoker or of having non-HDL cholesterol 50 mg/dl higher. The consistent association of specific clusters of MetS components with extremely thick (older) large artery cross-culturally suggests that identification of those clusters in clinical practice will facilitate a personalized health care and a better - i.e. more healthy and cost-effective - prevention of major cardiovascular (CV) events. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

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