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Relationship between lamina cribrosa curvature and the microvasculature in treatment-naïve eyes.

Authors
  • Kim, Ji-Ah1
  • Kim, Tae-Woo1
  • Lee, Eun Ji2
  • Girard, Michael J A3, 4
  • Mari, Jean Martial5
  • 1 Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea. , (North Korea)
  • 2 Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, South Korea [email protected] , (North Korea)
  • 3 Department of Biomedical Engineering, National University of Singapore, Singapore, Singapore. , (Singapore)
  • 4 Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. , (Singapore)
  • 5 GePaSud, Universite de la Polynesie Francaise, Faa'a, French Polynesia. , (French Polynesia)
Type
Published Article
Journal
British Journal of Ophthalmology
Publisher
BMJ
Publication Date
Mar 01, 2020
Volume
104
Issue
3
Pages
398–403
Identifiers
DOI: 10.1136/bjophthalmol-2019-313996
PMID: 31097439
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To investigate the relationship between the lamina cribrosa (LC) curvature and the microvasculature within the LC in treatment-naïve eyes with normal-tension glaucoma (NTG) and in healthy eyes. Forty-one eyes with treatment-naïve NTG and 41 age and sex-matched healthy control eyes were included. The optic nerve head (ONH) area was scanned using spectral-domain optical coherence tomography (OCT) to examine the LC curvature quantified as the LC curvature index (LCCI). OCT angiography of the ONH area was performed to determine the LC vessel density (LCVD) in the en face images obtained from the layer segmented at the level of the LC. The LCVD was calculated as the percentage area occupied by vessels within the measured region. The LCCI was larger (9.53±1.33 vs 6.55±1.02, p<0.001) and LCVD was smaller (28.0%±6.1% vs 35.2±6.3%, p<0.001) in NTG eyes than in healthy eyes. There were overall significant associations of a smaller retinal nerve fibre layer (RNFL) thickness (p<0.001), a smaller visual field mean deviation (MD) (p=0.003) and a larger LCCI (p≤0.004) with a smaller LCVD. In NTG group, the LCVD was positively associated with the RNFL thickness (p=0.012) and visual field MD (p=0.023), and negatively associated with the axial length (p≤0.013) and LCCI (p≤0.007). In healthy group, a smaller RNFL thickness (p=0.023) was associated with a smaller LCVD. A larger LCCI was significantly associated with a smaller LCVD in treatment-naïve NTG eyes but not in healthy eyes, indicating that mechanical strain potentially influences the perfusion within the LC in eyes with NTG. © Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.

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