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The relationship between hiatus hernia and tricyclic antidepressants: a report of five cases.

Authors
Type
Published Article
Journal
The American journal of psychiatry
Publication Date
Volume
132
Issue
6
Pages
652–653
Identifiers
PMID: 1124813
Source
Medline
License
Unknown

Abstract

Of five patients who were receiving tricyclic antidepressants, two experienced an aggravation of preexisting hiatus hernia, and three with previously normal gastrointestinal X rays developed hiatal herination. The author suggests that this group of drugs may exert an anticholinergic effect on the esophageal sphincter and reduce the tone of the esophagogastric sphincter, thus aggravating existing hiatus hernia or causing its development.

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