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The relationship between genomic RNAs of polycythaemic forms of spleen focus-forming Friend virus and its helper virus.

Authors
  • Mol, J N
  • Vonk, W P
  • Pragnell, I B
  • Stoof, T J
Type
Published Article
Journal
The Journal of general virology
Publication Date
Jun 01, 1981
Volume
54
Issue
Pt 2
Pages
367–377
Identifiers
PMID: 6270255
Source
Medline
Language
English
License
Unknown

Abstract

We have studied the relationship between Friend spleen focus-forming virus (SFFV) and its helper lymphoid leukaemia virus (LLV) by comparing RNase T1 fingerprints of genomic RNAs. Our data indicate that about 70% of the SFFV sequence is a perfect copy of parts of the helper genome. We conclude that our SFFV and LLV isolates have co-evolved very closely and that SFFV-specific sequences are not identical in different Friend virus isolates.

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