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Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population

Authors
  • Zong, Yicen1
  • Yan, Jing1
  • Jin, Li1
  • Xu, Bo1
  • He, Zhen1
  • Zhang, Rong1
  • Hu, Cheng1
  • Jia, Weiping1
  • 1 Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai, 200233, China , Shanghai (China)
Type
Published Article
Journal
Hereditas
Publisher
Springer (Biomed Central Ltd.)
Publication Date
May 22, 2020
Volume
157
Issue
1
Identifiers
DOI: 10.1186/s41065-020-00136-y
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundNon-invasive diagnostic markers are of great importance for early screening nonalcoholic fatty liver disease (NAFLD). MicroRNAs (miRNAs) play significant roles in many metabolic disease, including NAFLD. Therefore, this study focusd on a Chinese population to explore the possible correlation between circulating miR-132 and NAFLD.ResultsSerum miR-132 was positively associated with NAFLD in non-type 2 diabetes mellitus (T2DM) groups by logistic regression (OR = 3.082 [1.057, 8.988], P = 0.039) after adjusting age, sex, and body mass index (BMI). Additionally, in non-T2DM subgroup, after adjusting age, sex, bmi, serum miR-132 was significantly associated with ALT (β ± SE = 0.005 ± 0.002, P = 0.018), TG (β ± SE = 0.072 ± 0.029, P = 0.015), FPG (β ± SE = 0.123 ± 0.058, P = 0.036), γ-GT (β ± SE = 0.002 ± 0.001, P = 0.047), apoE (β ± SE = 0.038 ± 0.002, P = 0.017) .ConclusionsSerum miR-132 was found to be associated with NAFLD risk in a Chinese cross-section study. This finding provides a prospective research direction for early screening and diagnosing NAFLD.

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