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Relationship between Auditory Evoked Potentials and Circadian Preference in Patients with Major Depressive Episodes

Authors
  • Park, Young-Min
Type
Published Article
Journal
Brain Sciences
Publisher
MDPI AG
Publication Date
Jun 12, 2020
Volume
10
Issue
6
Identifiers
DOI: 10.3390/brainsci10060370
PMID: 32545632
PMCID: PMC7349307
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Green

Abstract

Mood disorders often accompany circadian rhythm abnormalities. The serotonergic system (STS) is related to mood and circadian rhythm. This study aimed to test whether serotonergic neurotransmission, using the loudness dependence of auditory evoked potential (LDAEP), is associated with circadian preference in patients with major depressive disorder (MDD). Depression severity was assessed in 18–65-year-old outpatients ( n = 48) using the Beck Depression Inventory scores and Hamilton Depression Rating Scale at baseline. Additionally, various scales, including the Korean version of the Composite Scale of Morningness (K-CSM), Korean version of the Mood Disorder Questionnaire (K-MDQ), and Korean version of the Childhood Trauma Questionnaire (K-CTQ), were used. LDAEP was also measured at baseline. The subjects were divided into three groups according to the circadian preference using total K-CSM scores (morningness ( n = 10) vs intermediate ( n = 19) vs. eveningness ( n = 19)) and two groups according to median based on each K-CSM score, respectively (higher K-CSM ( n = 25) vs. lower K-CSM ( n = 23)). The bipolarity, suicidality, and age at onset differed among the three groups. Impulsivity, depression severity, suicidality, hopelessness, bipolarity, frequency of emotional abuse, and age at onset differed between the two group divisions. Thus, the STS might serve as the mediator between the circadian system and mood.

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