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Relationship between angiotensin-converting enzyme insertion/deletion gene polymorphism and prostate cancer susceptibility.

Authors
  • Wang, Zhong-Yang1
  • Li, Hong-Yan2
  • Jiang, Zong-Pei3
  • Zhou, Tian-Biao3
  • 1 Department of Urology Surgery, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China. , (China)
  • 2 Department of Nephrology, Huadu District People's Hospital, Southern Medical University, Guangzhou, China. , (China)
  • 3 Department of Nephrology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510655, China. , (China)
Type
Published Article
Journal
Journal of cancer research and therapeutics
Publication Date
Jun 01, 2018
Volume
14
Issue
Supplement
Identifiers
DOI: 10.4103/0973-1482.171366
PMID: 29970692
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Investigations on the relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and prostate cancer risk are conflicting. This meta-analysis was conducted to assess the relationship between ACE I/D gene polymorphism and prostate cancer risk. Reports were identified from PubMed, Cochrane Library, and China Biological Medicine (CBM)-disc (CBM database) on December 30, 2014, and eligible studies were recruited. ACE I/D gene polymorphism was not associated with prostate cancer risk for overall populations in this meta-analysis (D allele: Odds ratio [OR] =1.56, 95% confidence interval [95% CI]: 1.00-2.46, P = 0.05; DD genotype: OR = 1.74, 95% CI: 0.95-3.20, P = 0.07; II genotype: OR = 0.67, 95% CI: 0.39-1.15, P = 0.15). Furthermore, the association of ACE I/D gene polymorphism with colorectal cancer risk was not found for the Caucasians. Interestingly, ACE I/D gene polymorphism was associated with prostate cancer risk for the Asian population and Latino population. There was an association between ACE I/D gene polymorphism and prostate cancer risk for the Asians and Latino population in this meta-analysis. However, more investigations should be performed to confirm this relationship.

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