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Regulatory T cells in the control of host-microorganism interactions (*).

Authors
  • Belkaid, Yasmine
  • Tarbell, Kristin
Type
Published Article
Journal
Annual review of immunology
Publication Date
Jan 01, 2009
Volume
27
Pages
551–589
Identifiers
DOI: 10.1146/annurev.immunol.021908.132723
PMID: 19302048
Source
Medline
License
Unknown

Abstract

Each microenvironment requires a specific set of regulatory elements that are finely and constantly tuned to maintain local homeostasis. Various populations of regulatory T cells contribute to the maintenance of this equilibrium and establishment of controlled immune responses. In particular, regulatory T cells limit the magnitude of effector responses, which may result in failure to adequately control infection. However, regulatory T cells also help limit collateral tissue damage caused by vigorous antimicrobial immune responses against pathogenic microbes as well as commensals. In this review, we describe various situations in which the balance between regulatory T cells and effector immune functions influence the outcome of host-microorganism coexistence and discuss current hypotheses and points of polemic associated with the origin, target, and antigen specificity of both endogenous and induced regulatory T cells during these interactions.

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