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Regulatory T-cell generation and kidney allograft tolerance induced by mesenchymal stem cells associated with indoleamine 2,3-dioxygenase expression.

Authors
  • Ge, Wei
  • Jiang, Jifu
  • Arp, Jacqueline
  • Liu, Weihua
  • Garcia, Bertha
  • Wang, Hao
Type
Published Article
Journal
Transplantation Journal
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Dec 27, 2010
Volume
90
Issue
12
Pages
1312–1320
Identifiers
DOI: 10.1097/TP.0b013e3181fed001
PMID: 21042238
Source
Medline
License
Unknown

Abstract

IDO secreted by MSCs was responsible, at least in part, for induction of kidney allograft tolerance through generation of Tregs. This study supports the clinical application of MSCs in transplantation.

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