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Regulatory T cell deficient scurfy mice exhibit a Th2/M2-like inflammatory response in the skin.

Authors
  • Haeberle, Stefanie1
  • Raker, Verena2
  • Haub, Jessica2
  • Kim, Yong O3
  • Weng, Shih-Yen3
  • Yilmaz, Osman K1
  • Enk, Alexander1
  • Steinbrink, Kerstin2
  • Schuppan, Detlef4
  • Hadaschik, Eva N5
  • 1 Department of Dermatology, University of Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany. , (Germany)
  • 2 Department of Dermatology, University of Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany; Research Center for Immune Therapy, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany. , (Germany)
  • 3 Institute of Translational Immunology, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany. , (Germany)
  • 4 Institute of Translational Immunology, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany; Research Center for Immune Therapy, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany. , (Germany)
  • 5 Department of Dermatology, University of Heidelberg, Im Neuenheimer Feld 440, 69120 Heidelberg, Germany. Electronic address: [email protected] , (Germany)
Type
Published Article
Journal
Journal of dermatological science
Publication Date
Sep 01, 2017
Volume
87
Issue
3
Pages
285–291
Identifiers
DOI: 10.1016/j.jdermsci.2017.07.001
PMID: 28811075
Source
Medline
License
Unknown

Abstract

We show that Scurfy mice show a predominant AC-5 ANA pattern typical for mixed connective tissue disease as in scleroderma. The autoimmune inflammation in scurfy skin mainly consists of CD4+ T cells with Th2 differentiation and alternatively-activated (M2) macrophages as it is found in scleroderma with advanced fibrosis.

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