Affordable Access

[Regulatory mechanisms for the renin-angiotensin-aldosterone system].

Authors
  • Ichihara, Atsuhiro1
  • 1 Department of Endocrinology and Hypertension, Tokyo Women's Medical University.
Type
Published Article
Journal
Nihon rinsho. Japanese journal of clinical medicine
Publication Date
Sep 01, 2012
Volume
70
Issue
9
Pages
1477–1481
Identifiers
PMID: 23012790
Source
Medline
License
Unknown

Abstract

While the circulating renin-angiotensin-aldosterone system(RAAS) plays an important role in the regulation of the sodium and extracellular fluid balance and blood pressure, the tissue RAAS has been reported to be involved in the pathophysiology of organ damage in patients with hypertension and diabetes. However, the regulation of the tissue RAAS, that is the production of angiotensin II and aldosterone within the tissue independently of the circulating RAAS, remains undetermined in detail. The purpose of this article is to review the recent advances in tissue RAAS research with a particular focus on the roles of (pro)renin receptor in the pathological conditions and its physiological function.

Report this publication

Statistics

Seen <100 times