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Regulation of type 1 diabetes by NKT cells.

Authors
Type
Published Article
Journal
International Reviews of Immunology
Publisher
Informa UK Limited
Publication Date
Jun 16, 2007
Volume
26
Issue
1-2
Pages
49–72
Identifiers
DOI: 10.1080/08830180601070229
PMID: 17454264
Source
USPC - SET - SVS
License
White

Abstract

Type 1 diabetes is an autoimmune disease due to the destruction of insulin-producing pancreatic beta cells. Natural Killer T (NKT) cells are a T-cell subset that links the innate and adaptive immune systems. NKT cells play a key regulatory role in type 1 diabetes. The absence of NKT cells correlates with exacerbation of type 1 diabetes, whereas an increased frequency and/or activation of NKT cells prevents beta-cell autoimmunity. Various mechanisms are involved in the protective effect of NKT cells. The goal is now to translate knowledge gained from mouse models into human therapeutics.

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