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Regulation of Schwann cell function by the extracellular matrix.

Authors
  • Chernousov, Michael A1
  • Yu, Wei-Ming
  • Chen, Zu-Lin
  • Carey, David J
  • Strickland, Sidney
  • 1 Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania, USA.
Type
Published Article
Journal
Glia
Publisher
Wiley (John Wiley & Sons)
Publication Date
Nov 01, 2008
Volume
56
Issue
14
Pages
1498–1507
Identifiers
DOI: 10.1002/glia.20740
PMID: 18803319
Source
Medline
License
Unknown

Abstract

Laminins and collagens are extracellular matrix proteins that play essential roles in peripheral nervous system development. Laminin signals regulate Schwann cell proliferation and survival as well as actin cytoskeleton dynamics, which are essential steps for radial sorting and myelination of peripheral axons by Schwann cells. Collagen and their receptors promote Schwann cell adhesion, spreading, and myelination as well as neurite outgrowth. In this article, we will review the recent advances in the studies of laminin and collagen function in Schwann cell development.

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