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Regulation of lysyl-tRNA synthetase expression by histone-like protein H-NS of Escherichia coli.

Authors
  • K Ito
  • T Oshima
  • T Mizuno
  • Y Nakamura
Publication Date
Dec 01, 1994
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

The lysU gene encoding lysyl-tRNA synthetase of Escherichia coli is normally silent at low temperatures and is expressed by certain metabolites and stimuli. A novel class of lysU-constitutive mutations were isolated by random insertion mutagenesis. These mutations nullified the hns gene encoding a histone-like protein, H-NS, and affected thermoregulation of lysU.

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