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Regulation of connective tissue growth factor (ccn2*; ctgf) gene expression in human mesangial cells: modulation by HMG CoA reductase inhibitors (statins)

Authors
  • M Goppelt-Struebe
  • A Hahn
  • D Iwanciw
  • M Rehm
  • B Banas
Publisher
British Medical Journal Publishing Group
Publication Date
Jun 01, 2001
Source
PMC
Keywords
Disciplines
  • Biology
  • Pharmacology
License
Unknown

Abstract

Aim—Connective tissue growth factor (ccn; ctgf) gene expression is upregulated in fibrotic renal glomeruli. Therefore, the regulation and pharmacological modulation of ccn2 (ctgf) mRNA expression was investigated in a human renal mesangial cell line.

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