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Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus.

Authors
  • Shafrir, Eleazar
  • Ziv, Ehud
  • Saha, Asish K
  • Ruderman, Neil B
Type
Published Article
Journal
Diabetes/metabolism research and reviews
Publication Date
Jan 01, 2002
Volume
18
Issue
3
Pages
217–223
Identifiers
PMID: 12112940
Source
Medline
License
Unknown

Abstract

Since non-diabetic Psammomys on a LE diet already show insulin resistance in the fed state, the sustained low malonyl-CoA levels in these animals imply a readiness for the oxidation of fatty acids. In a desert gerbil, adjusted to a food-scarce environment, such a continuing utilization of fatty acids as energy substrate by muscle would preserve the available glucose for glucose-dependent tissues and would diminish the need for gluconeogenesis.

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