Affordable Access

deepdyve-link
Publisher Website

Regulation of Metabolism Across Different Subsets of T Cells in Cancer.

Authors
  • Luo, Xuerui1
  • Zhu, Fuxiang1
  • Chen, Zuojia2
  • Li, Dan3, 4
  • Li, Bin5, 6, 7
  • 1 Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Shanghai, 200031, China. , (China)
  • 2 National Cancer Institute, Bethesda, MD, 20892, USA.
  • 3 Shanghai Institute of Immunology, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, China. , (China)
  • 4 Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. , (China)
  • 5 Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University, Shanghai, 200025, China. [email protected] , (China)
  • 6 School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China. [email protected] , (China)
  • 7 CAS Center for Excellence in Molecular Cell Science, CAS Key Laboratory of Molecular Virology and Immunology, Unit of Molecular Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, University of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200025, China. [email protected] , (China)
Type
Published Article
Journal
Advances in experimental medicine and biology
Publication Date
Jan 01, 2017
Volume
1011
Pages
197–209
Identifiers
DOI: 10.1007/978-94-024-1170-6_6
PMID: 28875491
Source
Medline
Keywords
License
Unknown

Abstract

T cells play a critical role to defend against tumor and maintain immune homeostasis. The diverse functions of T cells require precise regulation of metabolic pathways. Recent studies reveal that metabolic changes are tightly linked to the activation and function of T cells. Given the importance of these cells in tumor progression, it is important to understand how the tumor microenvironment regulates metabolism of T cells and how the metabolic reprogramming of T cells affects tumor growth. Here, we review new findings and discuss how metabolic reprogramming of different types of T cells affects the immune response in tumors.

Report this publication

Statistics

Seen <100 times