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The Regulation of Marrow Fat by Vitamin D: Molecular Mechanisms and Clinical Implications.

Authors
  • Sadie-Van Gijsen, Hanel1
  • 1 Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University Tygerberg Campus, Francie van Zijl Drive, PO Box 241, Parow, Cape Town, 8000, South Africa. [email protected] , (South Africa)
Type
Published Article
Journal
Current osteoporosis reports
Publication Date
Nov 20, 2019
Identifiers
DOI: 10.1007/s11914-019-00546-6
PMID: 31749086
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To review the available literature regarding a possible relationship between vitamin D and bone marrow adipose tissue (BMAT), and to identify future avenues of research that warrant attention. Results from in vivo animal and human studies all support the hypothesis that vitamin D can suppress BMAT expansion. This is achieved by antagonizing adipogenesis in bone marrow stromal cells, through inhibition of PPARγ2 activity and stimulation of pro-osteogenic Wnt signalling. However, our understanding of the functions of BMAT is still evolving, and studies on the role of vitamin D in modulating BMAT function are lacking. In addition, many diseases and chronic conditions are associated with low vitamin D status and low bone mineral density (BMD), but BMAT expansion has not been studied in these patient populations. Vitamin D suppresses BMAT expansion, but its role in modulating BMAT function is poorly understood.

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