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Regulation of human affective responses by anterior cingulate and limbic mu-opioid neurotransmission.

Authors
  • Zubieta, Jon-Kar
  • Ketter, Terence A
  • Bueller, Joshua A
  • Xu, Yanjun
  • Kilbourn, Michael R
  • Young, Elizabeth A
  • Koeppe, Robert A
Type
Published Article
Journal
Archives of General Psychiatry
Publisher
American Medical Association
Publication Date
Nov 01, 2003
Volume
60
Issue
11
Pages
1145–1153
Identifiers
PMID: 14609890
Source
Medline
License
Unknown

Abstract

These data demonstrate dynamic changes in mu-opioid neurotransmission in response to an experimentally induced negative affective state. The direction and localization of these responses confirms the role of the mu-opioid receptor system in the physiological regulation of affective experiences in humans.

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