Regulation of Gene Expression in Downstream Signaling Molecules by Herbal Compound in Insulin Resistant Diabetic Rats

Wilbert S Aronow; AA, Jafri; SB, Sharma; K, Luthra; M, Mehndiratta; N, Khurana; UR, Singh

doi:10.4172/2327-5162.1000243

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Regulation of Gene Expression in Downstream Signaling Molecules by Herbal Compound in Insulin Resistant Diabetic Rats

Authors

Wilbert S Aronow
AA, Jafri
SB, Sharma
K, Luthra
M, Mehndiratta
N, Khurana
UR, Singh¹

¹ Department of Biochemistry, University College of Medical Sciences (University of Delhi), Dilshad Garden, Delhi, India

Type

Published Article

Journal

Alternative & Integrative Medicine

Publisher

OMICS Publishing Group

Publication Date

Jan 20, 2017

Accepted Date

Jun 19, 2017

Volume

06

Issue

03

Identifiers

DOI: 10.4172/2327-5162.1000243

Source

MyScienceWork

Keywords

Eugenia Jambolana; Type 2 Diabetes; Ppar γ; Irs-1; Irs-2; Pioglitazone; Insulin Resistance

License

Green

Abstract

Background: In previous studies, Sharma et al. has already isolated an anti-hyperglycemic compound from the fruit pulp of Eugenia jambolana using HPLC and other chromatographic techniques. However, the effect of anti-hyperglycemic compound (FIIc) on the expression of PPAR gamma, IRS-1 and IRS-2 in high sucrose diet induced type 2 diabetic rats has not been studied so far.

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