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Regulation of colorectal carcinoma stemness, growth, and metastasis by an miR-200c-Sox2-negative feedback loop mechanism.

Authors
  • Lu, Yan-Xia1
  • Yuan, Li1
  • Xue, Xiao-Lei1
  • Zhou, Min1
  • Liu, Yan1
  • Zhang, Chao2
  • Li, Jing-Ping1
  • Zheng, Lin1
  • Hong, Min1
  • Li, Xue-Nong3
  • 1 Authors' Affiliations: Department of Pathology, School of Basic Medical Sciences, Department of Pathology, Nanfang Hospital, Southern Medical University, Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou; and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China. , (China)
  • 2 Authors' Affiliations: Department of Pathology, School of Basic Medical Sciences, Department of Pathology, Nanfang Hospital, Southern Medical University, Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou; and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaAuthors' Affiliations: Department of Pathology, School of Basic Medical Sciences, Department of Pathology, Nanfang Hospital, Southern Medical University, Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou; and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China. , (China)
  • 3 Authors' Affiliations: Department of Pathology, School of Basic Medical Sciences, Department of Pathology, Nanfang Hospital, Southern Medical University, Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou; and Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China [email protected] , (China)
Type
Published Article
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Date
May 15, 2014
Volume
20
Issue
10
Pages
2631–2642
Identifiers
DOI: 10.1158/1078-0432.CCR-13-2348
PMID: 24658157
Source
Medline
License
Unknown

Abstract

Our findings indicate that miR-200c regulates Sox2 expression through a feedback loop and is associated with CRC stemness, growth, and metastasis.

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