Affordable Access

Regulation by the autophosphorylation site in overexpressed pp60c-src.

Authors
  • T E Kmiecik
  • P J Johnson
  • D Shalloway
Publication Date
Oct 01, 1988
Source
PMC
Keywords
License
Unknown

Abstract

We show that overexpressed pp60c-src is phosphorylated at Tyr-416 and has increased specific kinase activity when isolated from cells incubated with vanadate, a tyrosine phosphatase inhibitor. This supports the hypothesis that transient Tyr-416 phosphorylation modulates the activity of overexpressed pp60c-src in vivo. Mutagenesis indicates that Tyr-416 modulates pp60v-src activity as well.

Report this publication

Statistics

Seen <100 times