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Regulation of 3-hydroxy-3-methylglutaryl coenzyme-A reductase activity in type II hyperlipoproteinaemia.

Authors
  • Betteridge, D J
  • Higgins, M J
  • Galton, D J
Type
Published Article
Journal
BMJ
Publisher
BMJ
Publication Date
Nov 29, 1975
Volume
4
Issue
5995
Pages
500–502
Identifiers
PMID: 172188
Source
Medline
License
Unknown

Abstract

The regulation of 3-hydroxy-3-methylglutaryl coenzyme-A reductase activity in leucocytes was studied in a family with familial type II hyperlipoproteinaemia (WHO classification). The propositus was heterozygous and 16 other members of the family were studied. Leucocytes were isolated by a relatively quick and simple procedure and used for enzyme estimations. The results suggest that measurement of the regulation of this enzyme in leucocytes may be helpful in the diagnosis and management of the condition.

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