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Regulatable Ras activity is critical for proper establishment and maintenance of polarity in Aspergillus fumigatus.

Authors
  • Fortwendel, Jarrod R
  • Juvvadi, Praveen R
  • Rogg, Luise E
  • Steinbach, William J
Type
Published Article
Journal
Eukaryotic Cell
Publisher
American Society for Microbiology
Publication Date
Apr 01, 2011
Volume
10
Issue
4
Pages
611–615
Identifiers
DOI: 10.1128/EC.00315-10
PMID: 21278230
Source
Medline
License
Unknown

Abstract

Here we show that expression of a constitutively activated RasA allele, as the sole source of Ras activity, revealed novel Ras-induced phenotypes, including excessive vacuolar expansion and spontaneous lysis of hyphal compartments. These findings highlight the requirement for balanced Ras activity in the establishment and maintenance of polarized growth in filamentous fungi.

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