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Regioselective electrochemical cyclobutanol ring expansion to 1-tetralones

Authors
  • Petti, A
  • Natho, P
  • Lam, K
  • Parsons, P
Publication Date
Dec 13, 2020
Source
Spiral - Imperial College Digital Repository
Keywords
License
Green
External links

Abstract

A mild electrochemical method for the regioselective preparation of 1‐tetralones under environmentally friendly conditions from readily available cyclobutanols was developed. A series of aromatic‐ and heteroaromatic‐fused 1‐tetralones was accessed through ring expansion of the functionalized cyclobutanols via electrochemical generation of alkoxy radicals and intramolecular cyclization.

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