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Regional myocardial substrate uptake in hypertensive rats: a quantitative autoradiographic measurement.

Authors
  • Yonekura, Y
  • Brill, A B
  • Som, P
  • Yamamoto, K
  • Srivastava, S C
  • Iwai, J
  • Elmaleh, D R
  • Livni, E
  • Strauss, H W
  • Goodman, M M
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Mar 22, 1985
Volume
227
Issue
4693
Pages
1494–1496
Identifiers
PMID: 3975623
Source
Medline
License
Unknown

Abstract

Severe hypertension causes global and regional changes in myocardial perfusion and substrate utilization. Regional perfusion and fatty acid utilization were evaluated by dual-tracer autoradiography in normotensive and hypertensive rats of the Dahl strain. The regional distributions of perfusion and fatty acid utilization were homogeneous in normotensive rats. Severe hypertension was associated with a homogeneous pattern of regional perfusion, but fatty acid utilization was focally decreased in the free wall of the left ventricle. The decrease in fatty acid uptake was associated with a concomitant increase in glucose utilization. These findings suggest that severe hypertension is associated with uniform myocardial perfusion and focal alterations in the substrates used for the performance of myocardial work.

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