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Regional Differences on Production of Chemokines in Gastric Mucosa Between Helicobacter pylori-Positive Duodenal Ulcer and Gastric Ulcer

Authors
  • Sato, Yuichi
  • Sugimura, Kazuhito
  • Mochizuki, Tsutomu
  • Honma, Terasu
  • Suriki, Hidehisa
  • Tashiro, Kazunori
  • Ishizuka, Kisei
  • Narisawa, Rintaro
  • Ichida, Takafumi
  • Van Thiel, David H.
  • Asakura, Hitoshi
Type
Published Article
Journal
Digestive Diseases and Sciences
Publisher
Springer-Verlag
Publication Date
Dec 01, 1999
Volume
44
Issue
12
Pages
2390–2396
Identifiers
DOI: 10.1023/A:1026610332680
Source
Springer Nature
Keywords
License
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Abstract

It is well known that antrum-predominantgastritis and pan-gastritis occurs in the patients withHelicobacter pylori-positive duodenal ulcer (DU) andgastric ulcer (GU), respectively. However, the role of chemokines in the pathogenesis of thesepathologies is unclear. We examined the regionaldifferences in mucosal chemokine production in patientswith DU and GU. The production of interleukin-8 (IL-8), growth-related gene (GRO) α, andmacrophage inflammatory protein (MIP)-1α wasgreater in the antrum than in the corpus in DU patients.In the patients with GU, monocyte chemoattractantprotein (MCP)-1 levels in the mucosa adjacent to ulcer weregreater than those away for the ulcer in the corpus. Thereduction in chemokine production occurring inassociation with the eradication of H. pylori differed between DU and GU patients in the antrum (IL-8,P = 0.0394; GROα, P = 0.0149; MIP-1α, P =0.0246; MCP-1, P = 0.0087). The data imply a differentpathogenesis may exist for the gastritis present in patients with DU and GU occurring in H.pylori-positive individuals.

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