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Regional chromosomal assignment of human renin gene to 1q12----qter and use in linkage studies in Charcot-Marie-Tooth disease.

Authors
  • Griffiths, L R
  • Nicholson, G A
  • Ross, D A
  • Zwi, M B
  • McLeod, J G
  • Mohandas, T
  • Morris, B J
Type
Published Article
Journal
Cytogenetics and cell genetics
Publication Date
Jan 01, 1987
Volume
45
Issue
3-4
Pages
231–233
Identifiers
PMID: 3319438
Source
Medline
License
Unknown

Abstract

The gene for renin, previously mapped to human chromosome 1, was further localized to 1q12----qter using human-mouse somatic cell hybrid DNAs. The renin DNA probe used (lambda HR5) could detect a HindIII restriction fragment length polymorphism. When used in studies of 12 informative families, no linkage could be found between the renin gene and Charcot-Marie-Tooth disease. Furthermore, an association of any renin allele with hypertension was not apparent.

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