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Regional brain variations of cytochrome oxidase activity in spontaneously hypertensive mice

Authors
  • Strazielle, C.1, 2
  • Lalonde, R.3
  • Thifault, S.3
  • Hamet, P.3
  • 1 EMI-INSERM 0014 and Service de Microscopie Electronique, Université Henri Poincaré, Vandoeuvre-les-Nancy, 54500, France , Vandoeuvre-les-Nancy
  • 2 Université Henri Poincaré, Nancy I, Service de Microscopie Electronique, Faculté de Médecine, 9 Avenue de la Forêt de Haye, Vandoeuvre-les-Nancy, 54500, France , Vandoeuvre-les-Nancy
  • 3 Laboratoire de Pathophysiologie Moléculaire de l’Hypertension, Hôtel-Dieu du Centre Hospitalier de l’Université de Montréal, Centre de Recherche, Montreal, Canada , Montreal
Type
Published Article
Journal
Experimental Brain Research
Publisher
Springer-Verlag
Publication Date
Mar 06, 2004
Volume
157
Issue
2
Pages
255–264
Identifiers
DOI: 10.1007/s00221-004-1841-1
Source
Springer Nature
Keywords
License
Yellow

Abstract

To explore the central disturbances resulting from blood pressure changes, spontaneously hypertensive mice (SHM) were compared to normotensive controls for cytochrome oxidase (CO) activity, an index of oxidative capacity in the central nervous system and a marker of long-term regional brain metabolism and neuronal activity. In all brain areas presenting significant enzymatic variations, only increases in CO activity were found in SHM, particularly the central autonomic network. However, only specific regions were affected, namely the insular cortex and the hypothalamic nuclei principally involved in high-order autonomic control. Altered limbic structures included the lateral septum, various hippocampal subregions, as well as prelimbic cortex. CO activity was also elevated in several forebrain regions, including those directly connected to the limbic system, such as the nucleus accumbens, the claustrum, and dorsomedial and reticular thalamic nuclei, as well as subthalamic and ventrolateral thalamic nuclei. In the brainstem, the only regions affected were the locus coeruleus, site of noradrenergic cell bodies, the trigeminal system, and four interconnected regions: the inferior colliculus, the paramedial reticular formation, the medial vestibular, and the cerebellar fastigial nuclei. These data show that specific regions modulating sympathetic nerve discharge are activated in young adult SHM, possibly due to mitochondrial dysfunction and excitotoxicity.

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