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Regional association of pCASL-MRI with FDG-PET and PiB-PET in people at risk for autosomal dominant Alzheimer's disease.

Authors
  • Yan, Lirong1, 2
  • Liu, Collin Y2, 3
  • Wong, Koon-Pong4
  • Huang, Sung-Cheng4
  • Mack, Wendy J5
  • Jann, Kay1, 2
  • Coppola, Giovanni6
  • Ringman, John M2, 3
  • Wang, Danny J J1, 2
  • 1 Laboratory of FMRI Technology (LOFT), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • 2 Department of Neurology, University of Southern California, Los Angeles, CA, USA.
  • 3 Alzheimer's Disease Research Center, University of Southern California, Los Angeles, CA, USA.
  • 4 Molecular and Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, USA.
  • 5 Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
  • 6 Semel Institute of Psychiatry and Biobehavioral Sciences UCLA, USA.
Type
Published Article
Journal
NeuroImage Clinical
Publisher
Elsevier
Publication Date
Jan 01, 2018
Volume
17
Pages
751–760
Identifiers
DOI: 10.1016/j.nicl.2017.12.003
PMID: 29527482
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Autosomal dominant Alzheimer's disease (ADAD) is a small subset of Alzheimer's disease that is genetically determined with 100% penetrance. It provides a valuable window into studying the course of pathologic processes that leads to dementia. Arterial spin labeling (ASL) MRI is a potential AD imaging marker that non-invasively measures cerebral perfusion. In this study, we investigated the relationship of cerebral blood flow measured by pseudo-continuous ASL (pCASL) MRI with measures of cerebral metabolism (FDG PET) and amyloid deposition (Pittsburgh Compound B (PiB) PET). Thirty-one participants at risk for ADAD (age 39 ± 13 years, 19 females) were recruited into this study, and 21 of them received both MRI and FDG and PiB PET scans. Considerable variability was observed in regional correlations between ASL-CBF and FDG across subjects. Both regional hypo-perfusion and hypo-metabolism were associated with amyloid deposition. Cross-sectional analyses of each biomarker as a function of the estimated years to expected dementia diagnosis indicated an inverse relationship of both perfusion and glucose metabolism with amyloid deposition during AD development. These findings indicate that neurovascular dysfunction is associated with amyloid pathology, and also indicate that ASL CBF may serve as a sensitive early biomarker for AD. The direct comparison among the three biomarkers provides complementary information for understanding the pathophysiological process of AD.

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