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Regeneration of the lateral vestibulospinal tract in adult rats by transplants of embryonic brain tissue.

Authors
  • Ito, J
  • Murata, M
  • Kawaguchi, S
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
Jan 08, 1999
Volume
259
Issue
2
Pages
67–70
Identifiers
PMID: 10025559
Source
Medline
License
Unknown

Abstract

We transected the lateral vestibulospinal tract in the spinal cord of adult rats. In one group we performed simple transection, and in other group we transplanted the lesion with embryonic tissue. In rats receiving simple transection, there was no regeneration, but in 22% of the rats receiving transplants of embryonic tissue, the axon regrew beyond the transected site, regenerated on the denervated side, terminating in the normal targets. The present findings are contrary to the widely held view that the adult mammalian central vestibular system cannot be restored following damage.

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