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Is there regeneration of cholinergic axons through traumatic scar tissue in adult mammalian brain?

Authors
Type
Published Article
Journal
Experimental neurology
Publication Date
Volume
95
Issue
1
Pages
65–75
Identifiers
PMID: 3792482
Source
Medline
License
Unknown

Abstract

After a 2-mm coronal incision was made in the cerebral cortex of adult rats, cholinergic axonal reaction and growth were assessed by acetylcholinesterase histochemistry between 3 and 56 days postinjury. Early axonal reaction in the proximal stumps consisted of hypertrophy and terminal swellings, many with extended processes. Axonal fiber density rostral to the lesion remained constant throughout the observation period; caudally it was reduced but increased with time. Cholinergic fibers appeared to cross the lesion, although definitive tracing of individual fibers was not possible.

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