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Refractive Index Measurement of Pharmaceutical Solids: A Review of Measurement Methods and Pharmaceutical Applications.

Authors
  • Mohan, Shikhar1
  • Kato, Eiji2
  • Drennen, James K 3rd1
  • Anderson, Carl A3
  • 1 Division of Pharmaceutical, Social and Administrative Sciences, Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, Pennsylvania 15282; Division of Pharmaceutical, Social and Administrative Sciences, Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, Pennsylvania 15282.
  • 2 New Concept Product Initiative, Advantest Corporation, Sendai 989-3124, Japan. , (Japan)
  • 3 Division of Pharmaceutical, Social and Administrative Sciences, Duquesne Center for Pharmaceutical Technology, Duquesne University, Pittsburgh, Pennsylvania 15282; Division of Pharmaceutical, Social and Administrative Sciences, Duquesne University Graduate School for Pharmaceutical Sciences, Pittsburgh, Pennsylvania 15282. Electronic address: [email protected]
Type
Published Article
Journal
Journal of Pharmaceutical Sciences
Publisher
Elsevier
Publication Date
Nov 01, 2019
Volume
108
Issue
11
Pages
3478–3495
Identifiers
DOI: 10.1016/j.xphs.2019.06.029
PMID: 31325425
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Refractive index is an important optical parameter that can be used to characterize the physicochemical properties of pharmaceutical solids. The complexity of most drugs and solid oral dosage systems introduces challenges for refractive index measurement methods. These challenges are highlighted, and different types of measurement methods are discussed in this review article. These measurements provide pharmaceutical scientists the opportunity to improve the drug-development process and enhance product quality. Pharmaceutical applications range from identification and quantification of drug crystallinity and polymorphism to mechanical strength assessment of tablets. This review article surveys the literature and evaluates the current and potential future characterization of pharmaceutical solids using refractive index measurements. Copyright © 2019. Published by Elsevier Inc.

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