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Reflections on the Utility of the Retina as a Biomarker for Alzheimer’s Disease: A Literature Review

Authors
  • Ngolab, Jennifer1
  • Honma, Patrick1, 2
  • Rissman, Robert A.1
  • 1 University of California, San Diego, CA, USA , San Diego (United States)
  • 2 Neuroscience Graduate Program, University of California, San Francisco, CA, USA , San Francisco (United States)
Type
Published Article
Journal
Neurology and Therapy
Publisher
Springer Healthcare
Publication Date
Dec 12, 2019
Volume
8
Issue
Suppl 2
Pages
57–72
Identifiers
DOI: 10.1007/s40120-019-00173-4
Source
Springer Nature
Keywords
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Abstract

As a part of the central nervous system, the retina may reflect both physiologic processes and abnormalities related to diseases of the brain. Indeed, a concerted effort has been put forth to understand how Alzheimer’s disease (AD) pathology may manifest in the retina as a means to assess the state of the AD brain. The development and refinement of ophthalmologic techniques for studying the retina in vivo have produced evidence of retinal degeneration in AD diagnosed patients. In this review, we will discuss retinal imaging techniques implemented to study the changes in AD retina as well as highlight the recent efforts made to correlate such findings to other clinical hallmarks of AD to assess the viability of the retina as a biomarker for AD.

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