Affordable Access

deepdyve-link
Publisher Website

Reflections upon immunological mechanisms involved in fertility, pregnancy and parasite infections.

Authors
  • Persson, Gry1
  • Ekmann, Josephine Roth1
  • Hviid, Thomas Vauvert F2
  • 1 Department of Clinical Biochemistry, Centre for Immune Regulation and Reproductive Immunology (CIRRI), The ReproHealth Research Consortium ZUH, Zealand University Hospital, and Department of Clinical Medicine, University of Copenhagen, 10 Sygehusvej, 4000 Roskilde, Denmark. , (Denmark)
  • 2 Department of Clinical Biochemistry, Centre for Immune Regulation and Reproductive Immunology (CIRRI), The ReproHealth Research Consortium ZUH, Zealand University Hospital, and Department of Clinical Medicine, University of Copenhagen, 10 Sygehusvej, 4000 Roskilde, Denmark. Electronic address: [email protected] , (Denmark)
Type
Published Article
Journal
Journal of reproductive immunology
Publication Date
Aug 12, 2019
Volume
136
Pages
102610–102610
Identifiers
DOI: 10.1016/j.jri.2019.08.001
PMID: 31479960
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

During a pregnancy, the mother accepts her semi-allogeneic fetus with no signs of immunological rejection. Therefore, some modulation of the maternal immune system must occur. Similarly, changes in the host's immune system occurs during infections with parasites. In a study conducted in an endemic area in Bolivia, it has been reported that women infected with either the helminthic parasite roundworm or hookworm were estimated to give birth to either two more, or three fewer, children than uninfected, endemic women, respectively. Immune regulation by helminthic parasites is a rather well-researched concept, but there are few reports on the effects on human fecundity. The current review focuses on mechanisms of possible importance for especially the increased fertility rates in women infected with roundworm. The host immune response to roundworm has been hypothesized to be more favourable for a successful pregnancy because it bears resemblance to the anti-inflammatory immunological responses observed in pregnancy, steering the immunological response away from a pro-inflammatory state that seem to suppress fecundity. Further research into parasitic worm interactions, fertility, and the molecular mechanisms that they unfold may widen our understanding of the immunomodulatory pathways in both helminthic infections and in fertility and pregnancy. Copyright © 2019 Elsevier B.V. All rights reserved.

Report this publication

Statistics

Seen <100 times