The germ lineage is considered to be immortal. In the quest to extend lifespan, a possible strategy is to drive germ-line traits in somatic cells, to try to confer some of the germ lineage s immortality on the somatic body. Notably, a study inCaenorhabditis eleganssuggested that expression of germ-line genes in the somatic cells of long-liveddaf-2mutants confers some ofdaf-2 s long lifespan. Specifically, mRNAs encoding components ofC. elegansgerm granules (P granules) were up-regulated indaf-2mutant worms, and knockdown of individual P-granule and other germ-line genes indaf-2young adults modestly reduced their lifespan. We investigated the contribution of a germ-line program todaf-2 s long lifespan and also tested whether other mutants known to express germ-line genes in their somatic cells are long-lived. Our key findings are as follows. (i) We could not detect P-granule proteins in the somatic cells ofdaf-2mutants by immunostaining or by expression of a P-granule transgene. (ii) Whole-genome transcript profiling of animals lacking a germ line revealed that germ-line transcripts are not up-regulated in the soma ofdaf-2worms compared with the soma of control worms. (iii) Simultaneous removal of multiple P-granule proteins or the entire germ-line program fromdaf-2worms did not reduce their lifespan. (iv) Several mutants that robustly express a broad spectrum of germ-line genes in their somatic cells are not long-lived. Together, our findings argue against the hypothesis that acquisition of a germ-cell program in somatic cells increases lifespan and contributes todaf-2 s long lifespan.